Serum cardiac troponins I and T in early posttraumatic rhabdomyolysis.

the plasma GSTA1-1 concentration increased; P ,0.0002 for the whole group) when compared with estradiol only. Sex-related differences in the expression of GST isoenzymes in liver were reported in rats [5] and mice [6] but not in humans. In female mice, ovariectomy resulted in increased liver GST activities that could be normalized by replacement of estrogen and progesterone [6]. In humans, men had higher plasma GST-alpha concentrations than women [3, 4]. In women, but not in men, an increase with age was noted [4]. This study shows that estradiol replacement did not decrease the relatively high plasma GSTA1-1 concentrations detected in elderly women. In contrast, the 8–10 days of replacement with estradiol combined with the progestogen NETA resulted in a 20% decrease of the median plasma GSTA1-1 concentration in postmenopausal women, indicating that the relatively high plasma GSTA1-1 concentrations observed in elderly women may be related to the low progestogen concentrations found in these women. The effect of hormonal replacement therapy on plasma GSTA1-1 concentrations in women reported in this study is on the same order of magnitude as the influence of gender and age on plasma GSTA1-1 concentrations. Although the effects of these variables are rather small, they should be kept in mind when plasma GSTA1-1 concentrations of groups of patients are compared with reference intervals obtained from the general population.